RT Book, Section
A1 Jensen, Robert T.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160011915
T1 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1160011915
RD 2024/04/19
AB Gastrointestinal  (GI)  neuroendocrine  tumors  (NETs)  are  tumors  derived  from  the  diffuse  neuroendocrine  system  of  the  GI  tract,  which  is  composed  of  amine-  and  acid-producing  cells  with  different  hormonal  profiles,  depending  on  the  site  of  origin.  NETs  of  the  GI  tract  share  many  features  with  other  NETs  throughout  the  body  and  were  historically  divided  into  GI-NETs  (in  the  GI  tract)  (also  frequently  called  carcinoid  tumors)  and  pancreatic  neuroendocrine  tumors  (pNETs),  although  in  newer  pathologic  classifications  they  are  all  classified  as  NETs  (Table  80-1).  These  tumors  originally  were  classified  as  APUDomas  (for  amine  precursor  uptake  and  decarboxylation),  as  were  pheochromocytomas,  NETs  in  other  locations,  melanomas,  and  medullary  thyroid  carcinomas,  because  they  share  certain  cytochemical  features  as  well  as  various  pathologic,  biologic,  and  molecular  features.  It  was  originally  proposed  that  APUDomas  had  a  similar  embryonic  origin  from  neural  crest  cells,  but  it  is  now  known  that  the  peptide-secreting  cells  are  not  of  neuroectodermal  origin.