RT Book, Section
A1 Lukehart, Sheila A.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155968737
T1 Endemic Treponematoses
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1155968737
RD 2024/04/19
AB The  endemic  treponematoses  are  chronic  diseases  that  are  transmitted  by  direct  contact,  usually  during  childhood,  and,  like  syphilis,  can  cause  severe  late  manifestations  years  after  initial  infection.  These  diseases  are  caused  by  very  close  relatives  of  Treponema  pallidum  subspecies  pallidum,  the  etiologic  agent  of  venereal  syphilis  (Chap.  177).  Yaws,  pinta,  and  endemic  syphilis  (bejel)  are  traditionally  distinguished  from  venereal  syphilis  by  mode  of  transmission,  age  of  acquisition,  geographic  distribution,  and  clinical  features;  however,  there  is  some  overlap  for  each  of  these  factors.  Our  “knowledge”  about  these  infections  is  based  on  observations  by  health  care  workers  who  have  visited  endemic  areas.  Except  for  recent  pilot  programs  of  mass  drug  administration  (MDA)  for  yaws,  virtually  no  well-designed  studies  of  the  natural  history,  diagnosis,  or  treatment  of  these  infections  have  been  conducted.  The  treponemal  infections  are  compared  and  contrasted  in  Table  178-1.