RT Book, Section
A1 Hoelzer, Dieter
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1159152901
T1 Acute Lymphoid Leukemia
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1159152901
RD 2024/04/25
AB In  acute  lymphoblastic  leukemia  (ALL),  the  malignant  clone  arises  from  hematopoietic  progenitors  in  the  bone  marrow  or  lymphatic  system  resulting  in  an  increase  of  immature  nonfunctioning  leukemic  cells.  Infiltration  of  bone  marrow  leads  to  anemia,  granulocytopenia,  and  thrombocytopenia  with  the  clinical  manifestations  of  fatigue,  weakness,  infection,  and  hemorrhages.  These  symptoms  are  more  often  the  reason  a  patient  first  seeks  medical  advice  rather  than  consequences  of  tumor  bulk,  such  as  lymph  node  enlargement,  hepatosplenomegaly  caused  by  leukemic  infiltration,  or  symptoms  of  the  central  nervous  system  (meningeosis  leukemica).