RT Book, Section
A1 Gupta, Kalpana
A1 Trautner, Barbara W.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1159153646
T1 Urinary Tract Infections, Pyelonephritis, and Prostatitis
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1159153646
RD 2024/04/19
AB Urinary  tract  infection  (UTI)  is  a  common  and  painful  human  illness  that,  fortunately,  is  rapidly  responsive  to  modern  antibiotic  therapy.  In  the  preantibiotic  era,  UTI  caused  significant  morbidity.  Hippocrates,  writing  about  a  disease  that  appears  to  have  been  acute  cystitis,  said  that  the  illness  could  last  for  a  year  before  either  resolving  or  worsening  to  involve  the  kidneys.  When  chemotherapeutic  agents  used  to  treat  UTI  were  introduced  in  the  early  twentieth  century,  they  were  relatively  ineffective,  and  persistence  of  infection  after  3  weeks  of  therapy  was  common.  Nitrofurantoin,  which  became  available  in  the  1950s,  was  the  first  tolerable  and  effective  agent  for  the  treatment  of  UTI.