RT Book, Section
A1 George, Jr., Alfred L.
A1 Neilson, Eric G.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1157019084
T1 Cellular and Molecular Biology of the Kidney
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1157019084
RD 2024/04/19
AB The  kidney  is  one  of  the  most  highly  differentiated  organs  in  the  body.  At  the  conclusion  of  embryologic  development,  nearly  30  different  cell  types  form  a  multitude  of  filtering  capillaries  and  segmented  nephrons  enveloped  by  a  dynamic  interstitium.  This  cellular  diversity  modulates  a  variety  of  complex  physiologic  processes.  Endocrine  functions,  the  regulation  of  blood  pressure  and  intraglomerular  hemodynamics,  solute  and  water  transport,  acid-base  balance,  and  removal  of  drug  metabolites  are  all  accomplished  by  intricate  mechanisms  of  renal  response.  This  breadth  of  physiology  hinges  on  the  clever  ingenuity  of  nephron  architecture  that  evolved  as  complex  organisms  came  out  of  water  to  live  on  land.