RT Book, Section
A1 Azizad-Pinto, Parisa
A1 Tapson, Victor F.
A2 Fuster, Valentin
A2 Harrington, Robert A.
A2 Narula, Jagat
A2 Eapen, Zubin J.
SR Print(0)
ID 1191188183
T1 RHEUMATOLOGIC DISEASES AND THE CARDIOVASCULAR SYSTEM
T2 Hurst's The Heart, 14e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071843249
LK accessmedicine.mhmedical.com/content.aspx?aid=1191188183
RD 2024/04/24
AB SummaryThis  chapter  discusses  the  cardiovascular  manifestations  of  various  rheumatological  conditions,  including  autoimmune  disorders  (see  accompanying  Hurst’s  Central  Illustration)  and  inherited  connective  tissue  diseases.  The  effects  of  the  autoimmune  disorders  on  the  cardiovascular  system  may  result  from  local  or  systemic  mechanisms.  Pericarditis,  valvular  disease,  coronary  artery  disease  and  accelerated  atherosclerosis,  cardiomyopathy,  and  heart  failure  are  common  cardiovascular  manifestations  of  the  autoimmune  rheumatological  disorders,  which  include  rheumatoid  arthritis,  adult-onset  Still  disease,  systemic  lupus  erythematosus,  antiphospholipid  syndrome,  dermatomyositis  and  polymyositis,  systemic  sclerosis,  seronegative  spondyloarthropathies,  and  systemic  vasculitides.  Notably,  40%  of  deaths  in  rheumatoid  arthritis  are  attributable  to  cardiovascular  disease  and  pericarditis  occurs  in  up  to  a  quarter  of  patients  with  adult-onset  Still  disease.  However,  cardiovascular  involvement  is  particularly  common  in  patients  with  systemic  lupus  erythematosus,  with  up  to  70%  of  patients  showing  signs  of  cardiovascular  disease.  The  inherited  connective  tissue  diseases  (including  Marfan  syndrome,  Loeys-Dietz  syndrome,  Ehlers-Danos  syndrome,  familial  thoracic  aortic  aneurysms  and  dissections,  pseudoxanthoma  elasticum,  and  osteogenesis  imperfecta)  are  generally  associated  with  vascular  aneurysms,  particularly  of  the  aorta,  and  aortic  dissections;  some  of  these  conditions  are  also  associated  with  valvular  disease.