RT Book, Section
A1 Kasper, Dennis L.
A1 Fauci, Anthony S.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Jameson, J. Larry
A1 Loscalzo, Joseph
SR Print(0)
ID 1128788740
T1 Adverse Drug Reactions
T2 Harrison's Manual of Medicine, 19e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071828529
LK accessmedicine.mhmedical.com/content.aspx?aid=1128788740
RD 2024/04/25
AB Adverse  drug  reactions  are  among  the  most  frequent  problems  encountered  clinically  and  represent  a  common  cause  for  hospitalization.  They  occur  most  frequently  in  pts  receiving  multiple  drugs  and  are  caused  by:  Errors  in  self-administration  of  prescribed  drugs  (quite  common  in  the  elderly);Exaggeration  of  intended  pharmacologic  effect  (e.g.,  hypotension  in  a  pt  given  antihypertensive  drugs);Concomitant  administration  of  drugs  with  synergistic  effects  (e.g.,  aspirin  and  warfarin);Cytotoxic  reactions  (e.g.,  hepatic  necrosis  due  to  acetaminophen);Immunologic  mechanisms  (e.g.,  quinidine-induced  thrombocytopenia,  hydralazine-induced  SLE);Genetically  determined  enzymatic  defects  (e.g.,  primaquine-induced  hemolytic  anemia  in  G6PD  deficiency);  orIdiosyncratic  reactions  (e.g.,  chloramphenicol-induced  aplastic  anemia).