RT Book, Section
A1 Goldstein, Jennifer B.
A1 Zhang, Zhijing
A1 Futreal, Andy
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
SR Print(0)
ID 1126745727
T1 Cancer Genomics
T2 The MD Anderson Manual of Medical Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071847940
LK accessmedicine.mhmedical.com/content.aspx?aid=1126745727
RD 2024/04/19
AB Over  the  past  50  years,  multiple  discoveries  have  had  an  impact  on  our  understanding  of  key  genomic  events  that  influence  the  development  of  malignant  growth.  After  many  large-scale  sequencing  projects  of  cancer  genomes,  we  now  understand  that  many  genetic  alterations  in  specific  cancer  genes  are  responsible  for  the  development  and  progression  of  the  disease.  These  alterations  may  occur  at  the  level  of  the  patient’s  germline,  predisposing  to  inherited  forms  of  cancer  that  may  develop  in  many  tissues  throughout  the  body.  Genetic  alterations  may  also  be  somatic,  or  newly  acquired  changes  within  the  genes  of  an  individual  cell  or  group  of  cells  over  time  and  due  to  environmental  stresses.  Somatic  alterations  may  come  in  many  forms,  including  single-base  substitutions;  insertions  or  deletions  of  DNA  fragments;  rearrangements  and  rejoining  of  DNA  from  alternative  locations  in  the  genome;  and  copy  number  increases  and  reductions.  Should  these  alterations  effect  key  cancer  genes,  malignancy  may  develop.