RT Book, Section
A1 Baljevic, Muhamed
A1 Jabbour, Elias
A1 O'Brien, Susan
A1 Kantarjian, Hagop M.
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
SR Print(0)
ID 1126739639
T1 Acute Lymphoblastic Leukemia
T2 The MD Anderson Manual of Medical Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071847940
LK accessmedicine.mhmedical.com/content.aspx?aid=1126739639
RD 2024/04/23
AB Acute  lymphoblastic  leukemia  (ALL)  is  characterized  by  the  proliferation  and  accumulation  of  lymphoid  progenitor  cells  in  the  blood,  bone  marrow,  and  other  tissues.  It  has  a  bimodal  distribution.  The  overall  age-adjusted  incidence  is  1.7  per  100,000  persons,  but  ALL  affects  4  to  5  per  100,000  persons  during  age  4  to  5  years  and  half  that  number  around  the  fifth  decade  of  life.  Approximately  60%  of  cases  are  diagnosed  in  patients  ≤20  years  old,  with  a  median  age  at  diagnosis  of  14  years.  In  2014,  the  American  Cancer  Society  estimated  that  approximately  6,000  individuals  would  be  diagnosed  with  ALL  that  year  (1,2).  Acute  lymphoblastic  leukemia  represents  20%  of  adult  leukemias  but  is  the  most  common  childhood  acute  leukemia,  representing  approximately  80%  of  cases  (1,2).