RT Book, Section
A1 Nyce, Andrew L.
A1 Lubkin, Cary L.
A1 Chansky, Michael E.
A2 Tintinalli, Judith E.
A2 Stapczynski, J. Stephan
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Cline, David M.
SR Print(0)
ID 1121514636
T1 Diabetic Ketoacidosis
T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794763
LK accessmedicine.mhmedical.com/content.aspx?aid=1121514636
RD 2024/04/19
AB Diabetic  ketoacidosis  (DKA)  is  an  acute,  life-threatening  complication  of  diabetes  mellitus.  DKA  occurs  predominantly  in  patients  with  type  1  (insulin-dependent)  diabetes  mellitus,  but  10%  to  30%  of  cases  occur  in  newly  diagnosed  type  2  (non–insulin-dependent)  diabetes  mellitus,  especially  in  African  Americans  and  Hispanics.1,2  Between  1993  and  2003,  the  yearly  rate  of  U.S.  ED  visits  for  DKA  was  64  per  10,000  with  a  trend  toward  an  increased  rate  of  visits  among  the  African  American  population  compared  with  the  Caucasian  population.3  Europe  has  a  comparable  incidence.  A  better  understanding  of  the  pathophysiology  of  DKA  and  an  aggressive,  uniform  approach  to  its  diagnosis  and  management  have  reduced  mortality  to  <5%  of  reported  episodes  in  experienced  centers.4  However,  mortality  is  higher  in  the  elderly  due  to  underlying  renal  disease  or  coexisting  infection  and  in  the  presence  of  coma  or  hypotension.