RT Book, Section
A1 Raasch, Ralph H.
A2 Tintinalli, Judith E.
A2 Stapczynski, J. Stephan
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Cline, David M.
SR Print(0)
ID 1121511375
T1 Pharmacology of Antimicrobials
T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794763
LK accessmedicine.mhmedical.com/content.aspx?aid=1121511375
RD 2024/04/19
AB Effective  antibacterial  drugs  can  either  inhibit  the  growth  of  (bacteriostatic)  or  kill  (bactericidal)  bacteria.  Antibacterial  effects  result  from  the  inhibition  of  cell  wall  synthesis,  inhibition  of  intrabacterial  protein  synthesis,  alteration  in  nucleic  acid  metabolism,  or  intrabacterial  enzyme  inhibition  (Table  163-1).  The  drug  mechanism  of  action  does  not  necessarily  correlate  with  bacteriostatic  or  bactericidal  effects,  because  the  latter  are  affected  also  by  the  concentration  of  antibiotic  to  which  bacteria  are  exposed.  Drugs  of  choice  for  most  infections  are  not  based  on  a  bacteriostatic  or  bactericidal  effect  of  an  agent,  but  rather  are  chosen  based  on  whether  the  drug  reaches  the  site  of  infection  in  adequate  quantities,  the  spectrum  of  the  agent,  its  safety,  and  cost.