RT Book, Section A1 LoVecchio, Frank A2 Tintinalli, Judith E. A2 Stapczynski, J. Stephan A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Cline, David M. SR Print(0) ID 1121499419 T1 Monoamine Oxidase Inhibitors T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794763 LK accessmedicine.mhmedical.com/content.aspx?aid=1121499419 RD 2024/04/20 AB Monoamine oxidase inhibitors (MAOIs) were the first class of antidepressants, but current use of these agents is primarily limited to treating atypical and refractory cases of depression (Table 179-1).1 Newer antidepressants have a more favorable side effect profile, less overdose toxicity, and no dietary restrictions. The declining popularity of oral MAOIs for the treatment of depression is partially offset by increasing use of agents in this class for the treatment of Parkinson's disease.2 In addition, a transdermal method of selegiline administration is approved for use in major depression and appears to avoid some of the worrisome aspects associated with traditional oral therapy.3,4,5