TY  - CHAP
M1  - Book, Section
TI  - Chapter 57. Amyloidosis
A1  - Palmer, Shanique R.
A1  - Mueller, Paul S.
A1  - Gertz, Morie
A2  - Imboden, John B.
A2  - Hellmann, David B.
A2  - Stone, John H.
PY  - 2013
T2  - CURRENT Diagnosis & Treatment: Rheumatology, 3e
AB  - Amyloidosis  is  not  a  single  disease  but  a  heterogeneous  group  of  diseases  that  share  in  common  the  extracellular  deposition  of  insoluble  fibrillar  proteins  in  tissues  and  organs.  These  protein  deposits  derive  from  diverse  and  unrelated  serum  precursor  proteins,  yet  have  similar  beta-pleated  sheet  structural  conformations.  Furthermore,  all  forms  of  amyloid  display  apple-green  birefringence  when  stained  with  the  cotton-wool  dye  Congo  red  and  viewed  under  polarized  light.  Indeed,  this  observation  (via  tissue  biopsy)  remains  the  primary  means  of  establishing  the  diagnosis  of  amyloidosis.  Accumulation  of  amyloid  deposits  leads  to  tissue  and  organ  dysfunction,  which  in  turn  causes  clinical  symptoms  and,  for  some  patients,  death.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/24
UR  - accessmedicine.mhmedical.com/content.aspx?aid=57275085
ER  -