TY - CHAP M1 - Book, Section TI - Renal Cell Carcinoma A1 - Motzer, Robert J. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Renal cell carcinomas account for 90–95% of malignant neoplasms arising from the kidney. Notable features include diagnosis without symptoms, resistance to cytotoxic agents, infrequent responses to biologic response modifiers such as interleukin (IL)-2, robust activity of antiangiogenesis-targeted agents, and a variable clinical course for patients with metastatic disease, including anecdotal reports of spontaneous regression. The remaining 5–10% of malignant neoplasms arising from the kidney are transitional cell carcinomas (urothelial carcinomas) originating in the lining of the renal pelvis. See Chap. 82 for transitional cell carcinomas. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156514368 ER -