TY  - CHAP
M1  - Book, Section
TI  - Acute Renal Failure
A1  - Kasper, Dennis L.
A1  - Fauci, Anthony S.
A1  - Hauser, Stephen L.
A1  - Longo, Dan L.
A1  - Jameson, J. Larry
A1  - Loscalzo, Joseph
PY  - 2016
T2  - Harrison's Manual of Medicine, 19e
AB  - Acute  renal  failure  (ARF)  or  acute  kidney  injury  (AKI),  defined  as  a  measurable  increase  in  the  serum  creatinine  (Cr)  concentration  (usually  relative  increase  of  50%  or  absolute  increase  by  44–88  μmol/L  [0.5–1.0  mg/dL]),  occurs  in  ~5–7%  of  hospitalized  pts.  It  is  associated  with  a  substantial  increase  in  in-hospital  mortality  and  morbidity.  AKI  can  be  anticipated  in  some  clinical  circumstances  (e.g.,  after  radiocontrast  exposure  or  major  surgery),  and  there  are  no  specific  pharmacologic  therapies  proven  helpful  at  preventing  or  reversing  the  condition.  Maintaining  optimal  renal  perfusion  and  intravascular  volume  appears  to  be  important  in  most  clinical  circumstances;  important  cofactors  in  AKI  include  hypovolemia  and  drugs  that  interfere  with  renal  perfusion  and/or  glomerular  filtration  (nonsteroidal  anti-inflammatory  drugs  [NSAIDs],  angiotensin-converting  enzyme  [ACE]  inhibitors,  and  angiotensin  receptor  blockers).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1128786584
ER  -