TY - CHAP M1 - Book, Section TI - Sepsis and Septic Shock A1 - Kasper, Dennis L. A1 - Fauci, Anthony S. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Jameson, J. Larry A1 - Loscalzo, Joseph PY - 2016 T2 - Harrison's Manual of Medicine, 19e AB - Possibly harmful systemic response: Two or more of the following: – Fever (oral temperature >38°C [100.4°F]) or hypothermia (oral temperature 24 breaths/min)– Tachycardia (>90 beats/min)– Leukocytosis (>12,000/μL), leukopenia (10% bands; may have a noninfectious etiologySepsis (or severe sepsis): Harmful systemic response (including some degree of organ hypofunction) with a proven or suspected microbial etiologySeptic shock: Sepsis with hypotension (arterial bp <90 mmHg or 40 mmHg below pt’s normal bp for at least 1 h despite fluid resuscitation) or need for vasopressors to maintain systolic bp ≥90 mmHg or mean arterial bp ≥70 mmHg SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1128781937 ER -