TY - CHAP M1 - Book, Section TI - Pulmonary Clearance of Infectious Agents A1 - Standiford, Theodore J. A1 - Toews*, Galen B. A1 - Huffnagle, Gary B. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. Y1 - 2015 N1 - T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - The primary function of the lungs is the exchange of gases at a rate required to support tissue metabolism. During gas exchange, the lung is continuously exposed to a varied burden of foreign substances, including infectious agents. In addition, the lung is repeatedly challenged with microbes via aspiration of secretions from the upper respiratory tract, particularly during sleep. The lung must defend itself against this potentially hostile environment while maintaining the alveolar architecture required for adequate gas exchange. This group of nonrespiratory functions has been collectively termed pulmonary host defenses.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122368239 ER -