TY - CHAP M1 - Book, Section TI - THE URINARY SYSTEM A1 - Lorenzo, Armando J. A2 - Janson, Lee W. A2 - Tischler, Marc E. Y1 - 2018 N1 - T2 - The Big Picture: Medical Biochemistry AB - The urinary system, composed of kidneys, ureters, bladder, and urethra, is responsible for the excretion of waste products in urine and regulation of important ions and molecules in the body. The biochemical components of the basal lamina and varying cell types found in the renal corpuscle create the filtering mechanism that initiates this process. Ionic channels and pumps found in the nephron allow the final composition of the urine to be modified according to the needs of the body. This is regulated by various hormones that help regulate sodium, potassium, chloride, calcium, magnesium, ammonia/acid–base balance, total body water, blood pressure, and other molecules and ions. The renin–angiotensin–aldosterone hormonal system as well as vasopressin and atrial naturetic peptide are keys in this process. Finally, the kidneys are essential for red blood cells production via erythropoietin synthesis and also add an essential biochemical step in the activation of vitamin D. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accessmedicine.mhmedical.com/content.aspx?aid=1152119006 ER -