TY - CHAP M1 - Book, Section TI - Edema A1 - Kasper, Dennis L. A1 - Fauci, Anthony S. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Jameson, J. Larry A1 - Loscalzo, Joseph Y1 - 2016 N1 - T2 - Harrison's Manual of Medicine, 19e AB - Soft tissue swelling due to abnormal expansion of interstitial fluid volume. Edema fluid is a plasma transudate that accumulates when movement of fluid from vascular to interstitial space is favored. Because detectable generalized edema in the adult reflects a gain of ≥3 L, renal retention of salt and water is necessary for edema to occur. Distribution of edema can be an important guide to cause. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1128782407 ER -