TY - CHAP M1 - Book, Section TI - Nonmalignant Pleural Effusions A1 - Heffner*, John E. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. PY - 2015 T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Nonmalignant pleural effusions develop as a consequence of diverse extrapleural conditions that secondarily affect the pleural space. These disorders include systemic diseases (e.g., lupus), disorders of individual organ systems (e.g., chronic pancreatitis, congestive heart failure [CHF]), trauma and surgery, and iatrogenic interventions (e.g., drug related). Pleural fluid (PF) collects by one or more mechanisms: (1) pleural injury that causes increased pleural membrane permeability and protein-rich exudates, (2) increased intravascular hydrostatic forces and/or decreased oncotic forces that cause protein-poor transudates, and (3) extravasation of fluid from lymphatic or vascular structures or from an adjacent body compartment into the pleural space.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1129858041 ER -