TY  - CHAP
M1  - Book, Section
TI  - Chapter 24. Minimal Change Disease
A1  - Kamil, Elaine S.
A2  - Lerma, Edgar V.
A2  - Berns, Jeffrey S.
A2  - Nissenson, Allen R.
PY  - 2009
T2  - CURRENT Diagnosis & Treatment: Nephrology & Hypertension
AB  - Minimal  change  disease  (MCD)  is  a  term  used  to  describe  the  pathologic  findings  in  a  group  of  patients  who  present  with  heavy  proteinuria,  typically  leading  to  nephrotic  syndrome.  On  renal  biopsy  the  findings  include  apparently  normal  glomeruli  on  light  microscopy,  negative  immunofluorescence,  and  diffuse  podocyte  foot  process  effacement  on  electron  microscopy.  While  occasionally  MCD  may  be  secondary  to  another  condition  such  as  lymphoma,  in  the  majority  of  cases  MCD  is  one  of  the  idiopathic  renal  diseases.  Because  MCD  is  most  likely  to  be  the  diagnosis  in  children  presenting  with  the  nephrotic  syndrome,  the  majority  of  children  do  not  undergo  a  kidney  biopsy,  but  receive  empiric  treatment  without  one.  Seventy  percent  of  children  with  MCD  present  before  age  5  years,  and  20–30%  of  adolescents  who  present  with  nephrotic  syndrome  have  MCD.  Nevertheless,  MCD  is  the  third  commonest  finding  in  adults  with  nephrotic  syndrome,  after  membranous  nephropathy  and  focal,  segmental  glomerulosclerosis.  The  typical  patient  with  MCD  responds  to  therapy  but  experiences  recurrent  relapses.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=6335619
ER  -