TY - CHAP M1 - Book, Section TI - DNA/RNA FUNCTION AND PROTEIN SYNTHESIS A1 - Janson, Lee W. A1 - Tischler, Marc E. PY - 2018 T2 - The Big Picture: Medical Biochemistry AB - The nucleus is often represented as a relatively empty structure, containing only deoxyribonucleic acid (DNA) being replicated and transcribed along with a few accessory molecules to help in the process. To the contrary, the nucleus is actually a highly organized, membrane-bound structure that is literally filled with proteins, nucleotides, carbohydrates, and lipids with multiple functions. Various proteins are involved, along with the nuclear membrane, in the organization of chromosomes, which also helps to regulate the processes of DNA replication and transcription, and, subsequently, protein synthesis. Other proteins directly influence the expression of genes via direct interactions with specific nucleotide sequences. Post-translational modifications affect both protein function and direct particular proteins to intracellular and/or extracellular destinations. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1152118320 ER -