TY  - CHAP
M1  - Book, Section
TI  - Acute Tubulointerstitial Nephritis
A1  - Moledina, Dennis G.
A2  - Lerma, Edgar V.
A2  - Rosner, Mitchell H.
A2  - Perazella, Mark A.
PY  - 2017
T2  - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
AB  - ESSENTIALS  OF  DIAGNOSISClinical  suspicion  of  tubulointerstitial  nephritis  is  raised  by  acute  to  subacute  rise  in  serum  creatinine,  presence  of  sterile  pyuria,  and  exposure  to  offending  medications.Diagnosis  of  tubulointerstitial  nephritis  requires  a  kidney  biopsy.On  histology,  tubulointerstitial  nephritis  is  characterized  by  presence  of  lymphocytes  in  the  interstitium,  presence  of  lymphocytes  infiltrating  into  the  tubular  space  (“tubulitis”),  and  varying  degree  of  interstitial  eosinophils.  The  glomeruli  are  usually  spared  except  in  nonsteroidal  anti-inflammatory  drug-induced  tubulointerstitial  nephritis,  which  may  show  global  foot  process  effacement.Medications  are  the  most  common  cause  of  tubulointerstitial  nephritis  in  the  United  States;  autoimmune  diseases  are  an  uncommon  etiology  of  tubulointerstitial  nephritis  in  the  elderly,  but  may  be  seen  in  the  young.Antibiotics,  proton  pump  inhibitors  and  nonsteroidal  anti-inflammatory  drugs  are  the  most  common  causes  of  tubulointerstitial  nephritis  in  the  United  States.  Immune  checkpoint  inhibitors  are  the  newest  class  of  drugs  implicated  in  the  tubulointerstitial  nephritis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1149114874
ER  -