The twelfth edition of Basic & Clinical Pharmacology
continues the important changes inaugurated in the eleventh edition, with
extensive use of full-color illustrations and expanded coverage of
transporters, pharmacogenomics, and new drugs. Case studies have been added
to several chapters and answers to questions posed in the case studies now
appear at the end of each chapter. As in prior editions, the book is
designed to provide a comprehensive, authoritative, and readable
pharmacology textbook for students in the health sciences. Frequent revision
is necessary to keep pace with the rapid changes in pharmacology and
therapeutics; the 2–3 year revision cycle of the printed text is among
the shortest in the field and the availability of an online version provides
even greater currency. In addition to the full-color illustrations, other
new features have been introduced. The Case Study Answer section at the end
of chapters will make the learning process even more interesting and
efficient. The book also offers special features that make it a useful
reference for house officers and practicing clinicians.
Information is organized according to the sequence used in
many pharmacology courses and in integrated curricula: basic principles;
autonomic drugs; cardiovascular-renal drugs; drugs with important actions on
smooth muscle; central nervous system drugs; drugs used to treat
inflammation, gout, and diseases of the blood; endocrine drugs;
chemotherapeutic drugs; toxicology; and special topics. This sequence builds
new information on a foundation of information already assimilated. For
example, early presentation of autonomic nervous system pharmacology allows
students to integrate the physiology and neuroscience they have learned
elsewhere with the pharmacology they are learning and prepares them to
understand the autonomic effects of other drugs. This is especially
important for the cardiovascular and central nervous system drug groups.
However, chapters can be used equally well in courses and curricula that
present these topics in a different sequence.
Within each chapter, emphasis is placed on discussion of drug groups and
prototypes rather than offering repetitive detail about individual drugs.
Selection of the subject matter and the order of its presentation are based
on the accumulated experience of teaching this material to thousands of
medical, pharmacy, dental, podiatry, nursing, and other health science
Major features that make this book
particularly useful in integrated curricula include sections that
specifically address the clinical choice and use of drugs in patients and
the monitoring of their effects—in other words, clinical
is an integral part of this text. Lists of the commercial
preparations available, including trade and generic names and dosage
formulations, are provided at the end of each chapter for easy reference by
the house officer or practitioner writing a chart order or prescription.
Significant revisions in this edition include:
• In addition to the Case Studies used to open many chapters, Case
Study Answers at the end of these chapters provide an introduction to the
clinical applications of the drugs discussed.
• A Drug Summary
Table is placed at the conclusion of most chapters; these provide a concise
recapitulation of the most important drugs.
• Many new
illustrations in full color provide significantly more information about
drug mechanisms and effects and help to clarify important concepts.
• Major revisions of the chapters on sympathomimetic, sympathoplegic,
antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and
antiviral drugs, prostaglandins, nitric oxide
, hypothalamic and pituitary
hormones, and immuno-pharmacology.
• Continued expansion of the
coverage of general concepts relating to newly discovered receptors,
receptor mechanisms, and drug transporters.
• Descriptions of
important new drugs released through August 2011.
An important related educational resource is Katzung & Trevor's
Pharmacology: Examination & Board Review,
ninth edition (Trevor AJ,
Katzung BG, & Masters SB: McGraw-Hill, 2010). This book provides a
succinct review of pharmacology with over one thousand sample examination
questions and answers. It is especially helpful to students preparing for
board-type examinations. A more highly condensed source of information
suitable for review purposes is USMLE Road Map: Pharmacology,
edition (Katzung BG, Trevor AJ: McGraw-Hill, 2006).
This edition marks the 30th year of publication of Basic & Clinical
The widespread adoption of the first eleven editions
indicates that this book fills an important need. We believe that the
twelfth edition will satisfy this need even more successfully. Spanish,
Portuguese, Italian, French, Indonesian, Japanese, Korean, and Turkish
translations are available. Translations into other languages are under way;
the publisher may be contacted for further information.
I wish to acknowledge the prior and continuing efforts of
my contributing authors and the major contributions of the staff at Lange
Medical Publications, Appleton & Lange, and McGraw-Hill, and of our
editors for this edition, Donna Frassetto and Rachel D'Annucci Henriquez. I
also wish to thank my wife, Alice Camp, for her expert proofreading
contributions since the first edition.
edition is dedicated to the memory of James Ransom, PhD, the long-time
Senior Editor at Lange Medical Publications, who provided major inspiration
and invaluable guidance through the first eight editions of the book.
Without him, this book would not exist.
Suggestions and comments about Basic & Clinical Pharmacology
always welcome. They may be sent to me in care of the publisher.
Bertram G. Katzung, MD, PhD