Blood coagulation is a very delicately balanced system. When it functions as it should, the blood is maintained in a fluid state in the vasculature, yet rapidly clots to seal an injury. When hemostatic functions fail, hemorrhage or thromboembolic phenomena result. This chapter addresses molecular and biochemical features of the proteins of the coagulation system, and how they interact with cells and with one another to provide hemostasis in the living organism. We have grouped the coagulation factors as (1) the vitamin-K-dependent zymogens (prothrombin, and factors VII, IX, X, and protein C); (2) the soluble cofactors (protein S, factor V, factor VIII, and von Willebrand factor); (3) factor XI and the other “contact” factors; (4) cell-associated cofactors (tissue factor and thrombomodulin); (5) fibrinogen; (6) factor XIII and TAFI; and (7) the plasma coagulation protease inhibitors. Table 115–1 shows the major features of the coagulation factors addressed in this chapter. A model of the coagulation pathway is presented that is based on current understanding of cell–cell and cell–protein interactions that regulate hemostasis. This scheme emphasizes the importance of cellular localization and plasma protease inhibitors in confining the coagulation reactions to a specific site of vascular injury.

Table Graphic Jump Location
Table 115–1 Characteristics of Coagulation Proteins 

Acronyms and Abbreviations


Acronyms and abbreviations that appear in this chapter include: ADAMTS, a disintegrin and metalloproteinase with thrombospondin ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessMedicine Full Site: One-Year Subscription

Connect to the full suite of AccessMedicine content and resources including more than 250 examination and procedural videos, patient safety modules, an extensive drug database, Q&A, Case Files, and more.

$995 USD
Buy Now

Pay Per View: Timed Access to all of AccessMedicine

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.