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Tumors of the central nervous system (CNS) constitute a bleak but vitally important chapter of neurologic medicine. Their importance derives from their great variety; the numerous neurologic symptoms caused by their size, location, and invasive qualities; the destruction and displacement of tissues in which they are situated; the elevation of intracranial pressure they cause; and, most of all, their lethality. Slowly, this dismal state of affairs is changing as a result of advances in anesthesiology, stereotactic and microneurosurgical techniques, focused radiation therapy and the use of new chemotherapeutic agents.

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For clinicians, the following generalizations should be a matter of general knowledge about brain tumors.

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  1. Many tumors, both primary and secondary, occur in the cranial cavity and spinal canal. Certain ones are much more frequent than others and are prone to occur in particular age groups. Secondary metastatic deposits are more common than primary brain tumors in adults and the opposite is true in children. Furthermore, certain cancers (breast, lung, melanoma, renal cell cancer) display a tendency to metastasize to nervous tissue and many others do not do so.

  2. Some primary intracranial and spinal tumors, such as craniopharyngioma, meningioma, and schwannoma, have a disposition to grow in particular parts of the cranial cavity, thereby producing highly characteristic neurologic syndromes.

  3. The presence of diseases such as AIDS, inherited disorders such as neurofibromatosis, and systemic cancers predisposes to the development of tumors of the nervous system.

  4. The growth rates and invasiveness of tumors vary; some, like the glioblastoma, are highly malignant, invasive, and rapidly progressive and others, like the meningioma, are benign, slowly progressive, and compressive. These different qualities have substantial clinical implications, frequently providing the explanation of slowly or rapidly evolving clinical states and determining a good or poor prognosis.

  5. Systemic neoplasms, by producing special autoantibodies have remote effects on the nervous system, quite apart from those caused by their compressive, infiltrative, or metastatic actions. These remote effects, referred to as paraneoplasias, often constitute the initial or only clinical manifestation of the underlying neoplasm.

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An excellent general reference on brain tumors is the text edited by Kaye and Laws.

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Incidence of CNS Tumors and Their Types

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Currently, in each year there are an estimated 600,000 deaths from cancer in the United States. Of these, the number of patients who died of primary tumors of the brain seems comparatively small (approximately 20,000, half of them malignant gliomas), but in roughly another 130,000 patients the brain is affected at the time of death by metastases. Thus, in approximately 25 percent of all the patients with cancer, the brain or its coverings are involved by neoplasm at some time in the course of the illness. Among causes of death from intracranial disease in adults, tumor is exceeded in frequency only by stroke, whereas in children primary brain tumors constitute the most common solid tumor and represent 22 percent of all childhood neoplasms, second in frequency ...

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