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Inpatient neurologic consultations usually involve questions about specific disease processes or prognostication after various cerebral injuries. Common reasons for neurologic consultation include stroke (Chap. 370), seizures (Chap. 369), altered mental status (Chap. 25), headache (Chap. 14), and management of coma and other neurocritical care conditions (Chaps. 274 and 275). This chapter focuses on additional common reasons for consultation that are not addressed elsewhere in the text.

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Hyperperfusion States

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A group of neurologic disorders shares the common feature of hyperperfusion playing a key role in pathogenesis. These seemingly diverse syndromes include hypertensive encephalopathy, eclampsia, postcarotid endarterectomy syndrome, and toxicity from calcineurin-inhibitor medications. Modern imaging techniques and experimental models suggest that vasogenic edema is usually the primary process leading to neurologic dysfunction; therefore, prompt recognition and management of this condition should allow for clinical recovery if superimposed hemorrhage or infarction has not occurred.

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The brain's autoregulatory capability successfully maintains a fairly stable cerebral blood flow in adults despite alterations in systemic mean arterial pressure (MAP) ranging from 50–150 mm Hg. In patients with chronic hypertension, this cerebral autoregulation curve is shifted, resulting in autoregulation working over a much higher range of pressures (e.g., 70–175 mm Hg). In these hypertensive patients, cerebral blood flow is kept steady at higher MAP, but a rapid lowering of pressure can more easily lead to ischemia on the lower end of the autoregulatory curve. This autoregulatory phenomenon is achieved through both myogenic and neurogenic influences causing small arterioles to contract and dilate. When the systemic blood pressure exceeds the limits of this mechanism, breakthrough of autoregulation occurs, resulting in hyperperfusion via increased cerebral blood flow, capillary leakage into the interstitium, and resulting edema. The predilection of all of the hyperperfusion disorders to affect the posterior rather than anterior portions of the brain may be due to a lower threshold for autoregulatory breakthrough in the posterior circulation.

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While elevated or relatively elevated blood pressure is common in many of these disorders, some hyperperfusion states such as calcineurin-inhibitor toxicity occur with no apparent pressure rise. In these cases, vasogenic edema is likely due primarily to dysfunction of the capillary endothelium itself, leading to breakdown of the blood-brain barrier. It is useful to separate disorders of hyperper-fusion into those caused primarily by increased pressure and those due mostly to endothelial dysfunction from a toxic or autoimmune etiology (Table e47–1). In reality, both of these pathophysiologic processes are likely playing some role in each of these disorders.

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Table Graphic Jump Location
Table e47–1 Some Common Etiologies of Hyperperfusion Syndrome 

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