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AFRICAN TRYPANOSOMIASIS (SLEEPING SICKNESS)

For the treatment of West African trypanosomiasis, fexinidazole has been endorsed by the WHO for both early and CNS infections and will likely replace other therapies for all but advanced CNS disease.

AMEBIASIS

Molecular diagnosis of amebiasis is possible from multipathogen panels; they are sensitive and specific, but expensive

COCCIDIOSIS (CRYPTOSPORIDIOSIS, ISOSPORIASIS, CYCLOSPORIASIS, SARCOCYSTOSIS) & MICROSPORIDIOSIS

For the diagnosis of cyclosporiasis, molecular assays with high sensitivity and specificity, including multi-pathogen panels, are available.

TRICHOMONIASIS

The regimen of a 7-day course of metronidazole (500 mg twice daily) for trichomoniasis is recommended in HIV infected women and may become standard for other groups.

STRONGYLOIDIASIS

PCR and related molecular diagnostic methods are now useful diagnostic tests for strongyloidiasis.

ONCHOCERCIASIS

Moxidectin, approved by the FDA for the treatment of onchocerciasis, is well-tolerated and superior to ivermectin in suppressing skin microfilariae.

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