The original designation of “advanced maternal age” in the 1970s was based on what?
a. The risk of having a fetus with aneuploidy increases sharply when a woman will be 35 at delivery.
b. The risk of having a fetus with an anomaly increases sharply when a woman will be 35 at delivery.
c. The fetal loss rate attributable to amniocentesis was equivalent to the risk of having a fetus with trisomy 21 at age 35.
What is the closest approximation of aneuploidy prevalence using population-based registries?
A 33-year-old G0 presents for preconception consultation and inquires about risk factors for aneuploidy in a future pregnancy. Which of the following risk factors increases the risk for aneuploidy?
a. Increasing maternal age
b. Parental chromosomal rearrangement
c. Former pregnancy affected by aneuploidy
A 32-year-old multigravida is in your office for a routine prenatal visit. She has a 10-week dichorionic twin gestation that is the result of in vitro fertilization with implantation of two embryos. What is it the most appropriate way to counsel her regarding aneuploidy screening?
a. You are still under age 35, so no screening is indicated
b. Cell-free DNA performs as well in a twin gestation as in a singleton.
c. If they would not terminate a pregnancy affected by aneuploidy, screening is not recommended.
d. With a dizygotic twin pregnancy, the risk for trisomy 21 in one of the fetuses approximates the risk of a singleton fetus in a mother who is 35 years old.
A 32-year-old multigravida is in your office for a routine prenatal visit. She has a 10-week dichorionic twin gestation that is the result ...