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Basic & Clinical Pharmacology, Fourteenth Edition

Copyright © 2018 by McGraw-Hill Education. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

Previous editions copyright © 2015, 2012, 2010, 2009, 2007, 2004, 2001 by McGraw-Hill Companies, Inc.; copyright © 1998, 1995, 1992, 1989, 1987 by Appleton & Lange; copyright © 1984, 1982 by Lange Medical Publications.

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ISBN 978-1-259-64115-2

MHID 1-259-64115-5

ISSN 0891-2033

This book was set in Adobe Garamond by Cenveo® Publisher Services.

The editors were Michael Weitz and Peter Boyle.

The copyeditors were Caroline Define and Greg Feldman.

The production supervisor was Richard Ruzycka.

Project management provided by Neha Bhargava, Cenveo Publisher Services.

Cover photo: Tumor necrosis factor alpha (TNF-α) cytokine protein molecule, 3D rendering. Clinically used inhibitors include infliximab, adalimumab, certolizumab and etanercept.

Photo credit: Shutterstock.

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