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Chapter 5: Connective Tissue

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Which of the following connective tissue components is located in the ECM but not in the ground substance?

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a. Collagen bundles

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b. Fibronectin

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c. GAGs

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d. Hyaluronan

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e. Proteoglycans

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What cells numerous in loose connective tissue are filled with secretory granules and stain with metachromasia?

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a. Macrophages

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b. Mast cells

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c. Fibrocytes

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d. Active fibroblasts

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e. Leukocytes

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What is the first step of collagen production that occurs after the protein undergoes exocytosis?

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a. Cross-linking of collagen fibrils with a short linking collagen

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b. Removal of the terminal nonhelical domains by peptidases

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c. Hydroxylation of lysine and proline

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d. Assembly of subunits to form a larger structure

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e. Disulfide bond formation

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What is an important part of the role played by macrophages during maintenance and renewal of strong extracellular fibers in connective tissue?

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a. Storage for a major energy source needed for ECM maintenance

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b. Production of specific collagen subunits

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c. A sentinel function against invaders entering the ECM

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d. Secretion of matrix metalloproteinases

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e. Presentation of antigens important for assembly of collagen bundles

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Sulfated GAGs are important constituents of what extracellular structures?

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a. Hyaluronan

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b. Elastic fibers

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c. Type I collagen

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d. Proteoglycans

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e. Multiadhesive glycoproteins

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Which of the following contains binding sites for integrins and is an important part of the ECM in both loose connective tissue and dense irregular connective tissue?

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a. Aggrecan

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b. Fibronectin

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c. Perlecan

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d. Fibrillin

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e. Most types of collagen

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