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Chapter 3: The Nucleus

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Which of the following facilitates breakdown of the nuclear envelope during the onset of mitosis?

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a. Disassembly of nucleosomes in the associated constitutive heterochromatin

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b. Increased export of material by the nuclear pore complexes into the perinuclear space

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c. Phosphorylation of lamin subunits by a cyclin-dependent kinase (CDK)

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d. Activities triggered at a restriction point late in G1

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e. The activity of proteasomes

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Binding of histone H1 proteins to importins is important for which of the following?

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a. Transport through the nuclear pores complexes

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b. Properly directed vesicular transport through the Golgi apparatus

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c. Transport from the granular part of the nucleolus

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d. Further binding to the “linker DNA” and proper assembly of nucleosomes

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e. Phosphorylation of cyclins

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Which of the following is a region of chromatin that is well developed in large neurons active in protein synthesis?

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a. Heterochromatin

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b. The nucleolus

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c. The Nissl substance (neuronal RER)

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d. The Barr body

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e. The nucleosome

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Which of the following is found during meiosis but not mitosis?

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a. Chromatids

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b. Polar microtubules

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c. Metaphase

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d. Synapsis

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e. Cytokinesis

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Transitions in the cell cycle from one phase to the next are regulated by protein kinases whose activity depends on what other proteins?

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a. Tumor suppressors

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b. Cyclins

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c. Actins

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d. Lamins

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e. Importins

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Mitotic figures visible in a tissue section from the lining of the small intestine are most likely to belong to which of the following categories?

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a. Terminally differentiated cells

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b. Partially differentiated cells

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c. Blood cells

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