Dilated cardiomyopathy (DCM) is characterized by left ventricular (LV) enlargement and systolic dysfunction.
The prevalence of DCM is 1 in 2700, however, this is undoubtedly an underestimate.
Histologic findings include myocyte hypertrophy, myocyte loss, and interstitial fibrosis.
Approximately 35% of DCM cases are deemed idiopathic dilated cardiomyopathy (IDC) after detectable causes have been excluded (Fig. 24-1).
20% to 50% of IDC may be found in one or more family members, and if so, is termed familial dilated cardiomyopathy (FDC). Of these cases, approximately 20% to 25% have identifiable genetic mutations correlating with disease phenotype.
Diagnostic Criteria and Clinical Characteristics
Diagnostic Criteria Compatible With IDC
Diagnostic Algorithm for Dilated Cardiomyopathy (DCM).
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