(See Chap. 110) Hodgkin's disease occurs mainly in the age range of people who are of child-bearing age. However, Hodgkin's disease is not more common in pregnant than nonpregnant women. Hodgkin's disease is diagnosed in approximately 1 in 6,000 pregnancies. It generally presents as a nontender lymph node swelling, most often in the left supraclavicular region. It may be accompanied by B symptoms (fever, night sweats, unexplained weight loss). Excisional biopsy is the preferred diagnostic procedure as fine-needle aspiration cannot reveal the architectural framework that is an essential component of Hodgkin's disease diagnosis. The stage at presentation appears to be unaffected by pregnancy. Women diagnosed in the second and third trimester can be treated safely with combination chemotherapy, usually doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). In general, the patient in the first trimester is asymptomatic and a woman with a desired pregnancy can be followed until the second or third trimester when definitive multiagent chemotherapy, can be safely given. Radiation therapy is not given during pregnancy. If symptoms requiring treatment appear during the first trimester, anecdotal evidence suggests that Hodgkin's disease symptoms can be controlled with weekly low-dose vinblastine. Such an approach has been safely used to avoid termination of pregnancy. Pregnancy does not have an adverse effect on treatment outcome.